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SLC6A1 / GAT-1 Antibody (aa372-421)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30531 |
| Other Accession | 6529 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 67074 Da |
| Dilution | ELISA (1:10000), IHC-P (2.5 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 6529 |
|---|---|
| Other Names | SLC6A1, GABA transporter, GABA transporter 1, GABT1, GAT1, GABATHG, GABATR, GAT-1, GAT 1 |
| Target/Specificity | SLC6A1 Antibodyantibody detects endogenous levels of SLC6A1. |
| Reconstitution & Storage | PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C. |
| Precautions | SLC6A1 / GAT-1 Antibody (aa372-421) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC6A1 |
|---|---|
| Synonyms | GABATR, GABT1, GAT1 |
| Function | Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein. Presynapse {ECO:0000250|UniProtKB:P31648}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000250|UniProtKB:P31648} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
References
Nelson H.,et al.FEBS Lett. 269:181-184(1990).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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