TRIP / LRRFIP1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q32MZ4 |
Other Accession | 9208 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 89253 Da |
Dilution | IHC-P (10 µg/ml), |
Gene ID | 9208 |
---|---|
Other Names | LRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF2, LRR FLII-interacting protein 1, HUFI-1, Tcf9, Tcf-9, TRIP, NEDD8-conjugating enzyme, TAR RNA-interacting protein, Transcription factor 9, GC-binding factor 2, GCF-2 |
Reconstitution & Storage | PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | TRIP / LRRFIP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LRRFIP1 |
---|---|
Synonyms | GCF2, TRIP |
Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
Cellular Location | Nucleus. Cytoplasm. |
Tissue Location | Ubiquitously expressed. |
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Background
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
References
Reed A.L.,et al.J. Biol. Chem. 273:21594-21602(1998).
Wilson S.A.,et al.Nucleic Acids Res. 26:3460-3467(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Fong K.S.K.,et al.Genomics 58:146-157(1999).
Khachigian L.M.,et al.Circ. Res. 84:1258-1267(1999).
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