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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-GPR35 Antibody (Cytoplasmic Domain)
Anti-GPR35 Antibody (Cytoplasmic Domain)
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| IHC-P, ICC |
|---|---|
| Primary Accession | Q9HC97 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34072 Da |
| Dilution | ICC, IHC-P (5 - 9 µg/ml) |
| Gene ID | 2859 |
|---|---|
| Alias Symbol | GPR35 |
| Other Names | GPR35, KYNA receptor, Kynurenic acid receptor, G protein-coupled receptor 35, G-protein coupled receptor 35 |
| Target/Specificity | Human GPR35. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-GPR35 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR35 |
|---|---|
| Function | G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:16754668, PubMed:20361937, PubMed:35148838). Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand (PubMed:35148838). Stimulates lipid metabolism, thermogenic, and anti- inflammatory gene expression in adipose tissue once activated by kynurenic acid (By similarity). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid |
| Tissue Location | Predominantly expressed in immune and gastrointestinal tissues. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 467.50
Cat# ALS17468
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