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Anti-GPR52 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9Y2T5 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41354 Da |
| Dilution | IHC-P (3 - 9 µg/ml) |
| Gene ID | 9293 |
|---|---|
| Alias Symbol | GPR52 |
| Other Names | GPR52, Axor10, G protein-coupled receptor 52 |
| Target/Specificity | Human GPR52. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-GPR52 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508} |
|---|---|
| Function | Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in brain, especially in striatum. |
Research Areas
Citations (0)
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$ 467.50
Cat# ALS17523
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