Anti-Prostaglandin D2 Receptor Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q13258 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 40271 Da |
Dilution | IHC-P (15 - 20 µg/ml) |
Gene ID | 5729 |
---|---|
Alias Symbol | PTGDR |
Other Names | PTGDR, DP, Dp receptor, PGD receptor, Prostaglandin D2 receptor (DP), Prostanoid DP receptor, PTGDR1, PGD2 receptor, Prostaglandin DP receptor, AS1, ASRT1, Dp prostanoid receptor, DP1, Prostaglandin D2 receptor |
Target/Specificity | Human Prostaglandin D2 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-Prostaglandin D2 Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTGDR |
---|---|
Function | Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3- dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. |
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