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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain)
Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain)
Rabbit Anti Human Polyclonal Antibody
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Application 
| IHC-P |
|---|---|
| Primary Accession | P41145 |
| Predicted | Human, Rat, Rabbit, Monkey, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42645 Da |
| Dilution | IHC-P (4 µg/ml) |
| Gene ID | 4986 |
|---|---|
| Alias Symbol | OPRK1 |
| Other Names | OPRK1, Kappa-type opioid receptor, Opiate receptor, kappa-1, K-OR-1, KOR, Opioid receptor, kappa 1, OPRK, Ork1, Kappa opioid receptor, KOR-1, Opioid receptor kappa |
| Target/Specificity | Human Kappa Opioid Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OPRK1 |
|---|---|
| Synonyms | OPRK |
| Function | G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in brain and placenta. |
Research Areas
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Application Protocols
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$ 467.50
Cat# ALS17546
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