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Anti-CFI / Complement Factor I Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P05156
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 65750 Da
Dilution IHC-P (10 µg/ml), WB (1:200 - 1:2000)
Additional Information
Gene ID 3426
Alias Symbol CFI
Other Names CFI, AHUS3, C3BINA, C3b-inactivator, C3B/C4B inactivator, Complement component I, Complement component factor i, Factor I, FI, KAF, I factor, I factor (complement), C3b-INA, Complement factor I, Light chain of factor I
Target/Specificity Human 65 kD protein
Reconstitution & Storage Antiserum
PrecautionsAnti-CFI / Complement Factor I Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFI
Synonyms IF
Function Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:7360115, PubMed:17320177). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:2141838, PubMed:9605165, PubMed:12055245). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664).
Cellular Location Secreted, extracellular space. Secreted
Tissue Location Expressed in the liver by hepatocytes (PubMed:6327681). Also present in other cells such as monocytes, fibroblasts or keratinocytes (PubMed:6444659, PubMed:17320177)
Research Areas
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$ 467.50
Cat# ALS17749
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