Anti-C5AR1 / CD88 / C5a Receptor Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P21730 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 39336 Da |
Dilution | IHC-P (5 µg/ml), WB |
Gene ID | 728 |
---|---|
Alias Symbol | C5AR1 |
Other Names | C5AR1, C5A, C5a-R, C5a ligand, C5a receptor, CD88, C5a anaphylatoxin receptor, C5AR, C5R1, CD88 antigen |
Target/Specificity | The antibody recognizes human complement C5a and its dimer form. Reactivity to other species has not been tested |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-C5AR1 / CD88 / C5a Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | C5AR1 |
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Synonyms | C5AR, C5R1 |
Function | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high- affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles |
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