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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-ARID1B / BRIGHT Antibody (clone 2D2)
Anti-ARID1B / BRIGHT Antibody (clone 2D2)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q8NFD5 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b,k |
| Clone Names | 2D2 |
| Calculated MW | 243943 Da |
| Dilution | ELISA, IF (10 µg/ml), IHC-P (10 µg/ml), WB |
| Gene ID | 57492 |
|---|---|
| Alias Symbol | ARID1B |
| Other Names | ARID1B, 6A3-5, BRG1-associated factor 250b, BRG1-binding protein ELD/OSA1, BRIGHT, DAN15, ELD/OSA1, ELD (eyelid)/OSA protein, KIAA1235, MRD12, HOsa2, OSA2, Osa homolog 2, RP11-419L10.1, BAF250B, BRG1-binding protein hELD/OSA1, p250R |
| Target/Specificity | Human ARID1B |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-ARID1B / BRIGHT Antibody (clone 2D2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARID1B (HGNC:18040) |
|---|---|
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non- specifically (PubMed:14982958, PubMed:15170388). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:11988099} |
| Tissue Location | Widely expressed with high levels in heart, skeletal muscle and kidney. |
Research Areas
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$ 533.50
Cat# ALS17902
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