Anti-SRF / Serum Response Factor Antibody (aa41-90)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P11831 |
Predicted | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 51593 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 6722 |
---|---|
Alias Symbol | SRF |
Other Names | SRF, Serum response factor, MCM1 |
Target/Specificity | SRF (Ab-77) Antibody detects endogenous levels of total SRF protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-SRF / Serum Response Factor Antibody (aa41-90) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SRF |
---|---|
Function | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017} |
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