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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CHEMR23 / CMKLR1 Antibody (Internal)
Anti-CHEMR23 / CMKLR1 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | Q99788 |
| Predicted | Human, Mouse, Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42322 Da |
| Dilution | IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000) |
| Gene ID | 1240 |
|---|---|
| Alias Symbol | CMKLR1 |
| Other Names | CMKLR1, Chemokine receptor-like 1, DEZ, CHEMERINR, Resolvin E1 receptor, RVER1, Chemokine-like receptor 1, ChemR23, G-protein coupled receptor DEZ |
| Target/Specificity | Recognizes endogenous levels of CMKLR1 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CHEMR23 / CMKLR1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CMKLR1 (HGNC:2121) |
|---|---|
| Synonyms | CHEMR23, DEZ |
| Function | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Internalizes efficiently in response to RARRES2. |
| Tissue Location | Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes |
Research Areas
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$ 467.50
Cat# ALS18176
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