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Anti-AR / Androgen Receptor Antibody (aa611-660)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P10275 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 99188 Da |
| Dilution | IHC-P (1:200), WB (1:500 - 1:1000) |
| Gene ID | 367 |
|---|---|
| Alias Symbol | AR |
| Other Names | AR, Androgen receptor, Dihydrotestosterone receptor, DHTR, AIS, KD, NR3C4, HUMARA, SBMA, TFM, SMAX1, HYSP1 |
| Target/Specificity | Human Androgen Receptor |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-AR / Androgen Receptor Antibody (aa611-660) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AR |
|---|---|
| Synonyms | DHTR, NR3C4 |
| Function | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. |
| Cellular Location | Nucleus. Cytoplasm Note=Detected at the promoter of target genes (PubMed:25091737) Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. |
| Tissue Location | [Isoform 2]: Mainly expressed in heart and skeletal muscle. |
Research Areas
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Application Protocols
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