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CABC1 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • IF - CABC1 Antibody AM1890B
    Confocal immunofluorescent analysis of CABC1 Antibody (Cat#AM1890b) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
    detail
  • WB - CABC1 Antibody AM1890B
    CABC1 antibody (Cat. #AM1890b) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the CABC1 antibody detected the CABC1 protein (arrow).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, WB, E
Primary Accession Q8NI60
Other Accession NP_064632.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone/Animal Names 216CT7.5.1
Calculated MW 71950 Da
Additional Information
Gene ID 56997
Other Names Chaperone activity of bc1 complex-like, mitochondrial, Chaperone-ABC1-like, 2711-, aarF domain-containing protein kinase 3, ADCK3, CABC1
Target/Specificity This CABC1 monoclonal antibody is generated from mouse immunized with CABC1 recombinant protein.
Dilution IF~~1:10~50
WB~~1:500~1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCABC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COQ8A {ECO:0000303|PubMed:27499294, ECO:0000312|HGNC:HGNC:16812}
Function Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).
Cellular Location Mitochondrion. Membrane; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398}
Tissue Location Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.
Research Areas
Citations (0)
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Background

This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.

References

Lagier-Tourenne, C., et al. Am. J. Hum. Genet. 82(3):661-672(2008)
Mollet, J., et al. Am. J. Hum. Genet. 82(3):623-630(2008)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Iiizumi, M., et al. Cancer Res. 62(5):1246-1250(2002)

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$ 365.00
$ 140.00
Cat# AM1890B
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