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EIF4B Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23588 |
| Other Accession | NP_001408.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 355CT12.6.5 |
| Calculated MW | 69151 Da |
| Gene ID | 1975 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 4B, eIF-4B, EIF4B |
| Target/Specificity | This EIF4B monoclonal antibody is generated from mouse immunized with EIF4B recombinant protein. |
| Dilution | WB~~1:500 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EIF4B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EIF4B |
|---|---|
| Function | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
References
Mokas, S., et al. Mol. Biol. Cell 20(11):2673-2683(2009)
Rozovsky, N., et al. RNA 14(10):2136-2148(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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