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FSHB/FSH Antibody (Center)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P01225 |
| Other Accession | NP_000501.1, NP_001018090.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 |
| Clone/Animal Names | 365CT24.1.1 |
| Calculated MW | 14700 Da |
| Antigen Region | 36-64 aa |
| Gene ID | 2488 |
|---|---|
| Other Names | Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain, FSHB |
| Target/Specificity | This FSHB/FSH antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the Central region of human FSHB/FSH. |
| Dilution | WB~~1:150~1500 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FSHB/FSH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FSHB |
|---|---|
| Function | Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:24692546, PubMed:2494176). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). |
| Cellular Location | Secreted. Note=Efficient secretion requires dimerization with CGA |
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Provided below are standard protocols that you may find useful for product applications.
Background
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
References
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Corpuz, P.S., et al. Mol. Endocrinol. 24(5):1037-1051(2010)
Grigorova, M., et al. J. Clin. Endocrinol. Metab. 95(1):100-108(2010)
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
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