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THAP11 Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96EK4 |
| Other Accession | A5PKF5, NP_065190.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone/Animal Names | 364CT25.4.2 |
| Calculated MW | 34455 Da |
| Antigen Region | 165-193 aa |
| Gene ID | 57215 |
|---|---|
| Other Names | THAP domain-containing protein 11, THAP11 |
| Target/Specificity | This THAP11 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human THAP11. |
| Dilution | WB~~1:8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | THAP11 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THAP11 |
|---|---|
| Function | Transcription factor, which has both transcriptional activation and repression activities (PubMed:31905202). Also modulates chromatin accessibility (PubMed:38361031). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed:26416877). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (PubMed:28449119, PubMed:31905202). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (PubMed:31905202). |
| Cellular Location | Nucleus. Cytoplasm Note=In oocytes, detected in the ooplasm, without evidence of its presence in the nucleus (By similarity). Found in the nucleus of undifferentiated embryonic stem cells (PubMed:18585351). Evenly distributed between nucleus and cytoplasm in skin fibroblasts (PubMed:37148549). {ECO:0000250|UniProtKB:Q9JJD0, ECO:0000269|PubMed:18585351, ECO:0000269|PubMed:37148549} |
| Tissue Location | Expressed in skin fibroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
References
Zhu, C.Y., et al. Cell Death Differ. 16(3):395-405(2009)
Dejosez, M., et al. Cell 133(7):1162-1174(2008)
Roussigne, M., et al. Trends Biochem. Sci. 28(2):66-69(2003)
Ueki, N., et al. Nat. Biotechnol. 16(13):1338-1342(1998)
Li, S.H., et al. Genomics 16(3):572-579(1993)
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