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CCR7 Antibody (N-term) (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - CCR7 Antibody (N-term) (Ascites) AM2119a
    CCR7 Antibody (N-term)(Ascites)(Cat. #AM2119a) western blot analysis in HL-60 cell line lysates (35μg/lane).This demonstrates the CCR7 antibody detected the CCR7 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P32248
Other Accession NP_001829.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone/Animal Names 617CT2.2.1
Calculated MW 42874 Da
Antigen Region 11-37 aa
Additional Information
Gene ID 1236
Other Names C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1, EBI1, EBV-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, CCR7, CMKBR7, EBI1, EVI1
Target/Specificity This CCR7 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 11-37 amino acids from the N-terminal region of human CCR7.
Dilution WB~~1:200~3200
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCR7 Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR7
Synonyms CMKBR7, EBI1, EVI1
Function Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7
Research Areas
Citations (0)
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Background

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [provided by RefSeq].

References

Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Deguchi, K., et al. Anticancer Res. 30(6):2361-2366(2010)
Raynaud, C.M., et al. Clin Lung Cancer 11(3):187-191(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)

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$ 182.50
Cat# AM2119a
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