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GNAS Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - GNAS Antibody (Ascites) AM2129a
    GNAS Antibody(Ascites)(Cat. #AM2129a) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the GNAS antibody detected the GNAS protein (arrow).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q5FWY2
Other Accession P29797, Q8R4A8, P63095, P63094, P63092, P04896, Q63803, Q6R0H7, Q5JWF2
Reactivity Mouse
Predicted Human, Rat, Bovine, Hamster, Pig
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone/Animal Names 559CT 16.1.3
Calculated MW 44250 Da
Antigen Region 287-315 aa
Additional Information
Gene ID 2778
Other Names GNAS complex locus;GNAS;
Target/Specificity This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS.
Dilution WB~~1:300
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGNAS Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNAS {ECO:0000313|EMBL:AAH89157.2}
Cellular Location Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}
Citations (0)
citation

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Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

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$ 182.50
Cat# AM2129a
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