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FN3K Antibody (N-term)(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - FN3K Antibody (N-term)(Ascites) AM2193a
    FN3K Antibody (N-term) (Cat. #AM2193a) western blot analysis in K562 cell line lysates (35μg/lane).This demonstrates the FN3K antibody detected the FN3K protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H479
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 788CT24.5.1
Calculated MW 35171 Da
Additional Information
Gene ID 64122
Other Names Fructosamine-3-kinase, 271-, FN3K
Target/Specificity Purified His-tagged FN3K protein was used to produced this monoclonal antibody.
Dilution WB~~1:1000~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFN3K Antibody (N-term)(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FN3K {ECO:0000303|PubMed:14633848, ECO:0000312|HGNC:HGNC:24822}
Function Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).
Tissue Location Widely expressed (PubMed:11522682). Expressed in erythrocytes (PubMed:11016445).
Research Areas
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Background

May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme.

References

Delpierre G., et al. Diabetes 49:1627-1634(2000).
Yu L.-R., et al. J. Proteome Res. 6:4150-4162(2007).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).

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$ 162.50
Cat# AM2193a
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