|Application ||WB, E|
|Calculated MW||28138 Da|
|Other Names||Homeobox protein CDX-1, Caudal-type homeobox protein 1, CDX1|
|Target/Specificity||Purified His-tagged CDX1 protein was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).|
|Tissue Location||Intestinal epithelium.|
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Provided below are standard protocols that you may find useful for product applications.
Could play a role in the terminal differentiation of the intestine.
Bonner C.A., et al. Genomics 28:206-211(1995).
Mallo G.V., et al. Int. J. Cancer 74:35-44(1997).
Malakooti J., et al. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
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