|Application ||IF, WB, E|
|Other Accession||P63102, P63101, P63103, P29361|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27745 Da|
|Other Names||14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ|
|Target/Specificity||This YWHAZ antibody is generated from a mouse immunized with a recombinant protein from human YWHAZ.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||YWHAZ Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).|
|Cellular Location||Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Zupan L.A.,et al.J. Biol. Chem. 267:8707-8710(1992).
Seluja G.A.,et al.Biochim. Biophys. Acta 1395:281-287(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
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