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Ntrk3 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • WB - Ntrk3 Antibody AM8448b
    Western blot analysis of lysates from mouse brain, rat brain tissue lysate (from left to right), using Ntrk3 Antibody(Cat. #AM8448b). AM8448b was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 20μg per lane.
    detail
  • WB - Ntrk3 Antibody AM8448b
    Western blot analysis of lysate from human brain tissue lysate, using Ntrk3 Antibody(Cat. #AM8448b). AM8448b was diluted at 1:1000. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 20μg.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6VNS1
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone/Animal Names 1454CT394.87.35
Calculated MW 92760 Da
Antigen Region 1-322 aa
Additional Information
Gene ID 18213
Other Names NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC
Target/Specificity This Ntrk3 antibody is generated from a mouse immunized with a recombinant protein of human Ntrk3.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNtrk3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ntrk3
Synonyms TrkC
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads.
Research Areas
Citations (0)
citation

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Background

Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity).

References

Yamauchi J.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:14421-14426(2003).
Menn B.,et al.J. Comp. Neurol. 401:47-64(1998).
Ballif B.A.,et al.J. Proteome Res. 7:311-318(2008).

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$ 365.00
$ 140.00
Cat# AM8448b
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