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Natriuretic Peptide Receptor C Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P17342 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 1748CT403.18.42 |
| Calculated MW | 59808 Da |
| Gene ID | 4883 |
|---|---|
| Other Names | Atrial natriuretic peptide receptor 3, Atrial natriuretic peptide clearance receptor, Atrial natriuretic peptide receptor type C, ANP-C, ANPR-C, NPR-C, NPR3, ANPRC, C5orf23, NPRC |
| Target/Specificity | This Natriuretic Peptide Receptor C antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 200-420 amino acids from the human region of human Natriuretic Peptide Receptor C. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Natriuretic Peptide Receptor C Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPR3 |
|---|---|
| Synonyms | ANPRC, C5orf23, NPRC |
| Function | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
References
Lowe D.G.,et al.Nucleic Acids Res. 18:3412-3412(1990).
Porter J.G.,et al.Biochem. Biophys. Res. Commun. 171:796-803(1990).
Rae J.L.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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