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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > HK2 (Hexokinase II) Antibody
HK2 (Hexokinase II) Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P52789 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 1798CT748.15.25 |
| Calculated MW | 102380 Da |
| Gene ID | 3099 |
|---|---|
| Other Names | Hexokinase-2, 2.7.1.1, Hexokinase type II, HK II, Muscle form hexokinase, HK2 |
| Target/Specificity | This HK2 (Hexokinase II) antibody is generated from a mouse immunized with a recombinant protein between 1-170 amino acids from human HK2 (Hexokinase II). |
| Dilution | WB~~1:500-1:1000 IHC-P~~N/A E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HK2 (Hexokinase II) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HK2 (HGNC:4923) |
|---|---|
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). |
| Cellular Location | Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880) The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). |
| Tissue Location | Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Deeb S.S.,et al.Biochem. Biophys. Res. Commun. 197:68-74(1993).
Lehto M.,et al.Diabetologia 38:1466-1474(1995).
Malkki M.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Shinohara Y.,et al.Cancer Lett. 82:27-32(1994).
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$ 150.00
$ 385.00
Cat# AM8606b
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