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GNMT Antibody (C-term)
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q14749 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a,k |
| Clone/Animal Names | 1041CT18.2.3 |
| Calculated MW | 32742 Da |
| Gene ID | 27232 |
|---|---|
| Other Names | Glycine N-methyltransferase, 2.1.1.20, GNMT |
| Target/Specificity | This GNMT antibody is generated from a mouse immunized with a recombinant protein between 1-295 amino acids from the human GNMT. |
| Dilution | WB~~1:4000 FC~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNMT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNMT (HGNC:4415) |
|---|---|
| Function | Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L- homocysteine. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P13255}. |
| Tissue Location | Expressed only in liver, pancreas, and prostate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
References
Chen Y.-M.A.,et al.Int. J. Cancer 75:787-793(1998).
Chen Y.-M.A.,et al.Genomics 66:43-47(2000).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ogawa H.,et al.Comp. Biochem. Physiol. 106B:601-611(1993).
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