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RAB27B Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | O00194 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 1596CT245.254.49 |
| Calculated MW | 24608 Da |
| Gene ID | 5874 |
|---|---|
| Other Names | Ras-related protein Rab-27B, C25KG, RAB27B |
| Target/Specificity | This RAB27B antibody is generated from a mouse immunized with a recombinant protein of human RAB27B. |
| Dilution | WB~~1:2000 FC~~1:25 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB27B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB27B |
|---|---|
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). |
| Cellular Location | Membrane; Lipid-anchor. Late endosome |
| Tissue Location | Expressed primarily in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in targeting uroplakins to urothelial apical membranes.
References
Chen D.,et al.Biochem. Mol. Med. 60:27-37(1997).
Chen D.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Ramalho J.S.,et al.BMC Genet. 2:2-2(2001).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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