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Testicular Receptor 2 (TR2) Antibody
Rabbit polyclonal antibody.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q505F1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 64 KDa |
| Gene ID | 22025 |
|---|---|
| Gene Name | NR2C1 |
| Other Names | Nuclear receptor subfamily 2 group C member 1, Orphan nuclear receptor TR2, Testicular receptor 2, mTR2, Nr2c1 {ECO:0000312|MGI:MGI:1352465} |
| Target/Specificity | Fusion protein from the N-terminal region of mouse TR2. |
| Dilution | WB~~ 1:1000 |
| Format | neat serum. |
| Antibody Specificity | Specific for the ~64 kDa TR2 protein in Western blots of testes and nuclear extracts from MEL cell lines. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Testicular Receptor 2 (TR2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008).
References
Franco PJ, Li G, Wei LN (2003) Interaction of nuclear receptor
w
Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C. (2002) Suppression of estrogen receptor-mediated transcription a
2
Lin TJ, Yang RY, Lee HJ. (2008) Collective repression of the hepati
h
Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YTChang C, Yamamoto M, Tanimoto K, Engel JD. “Embryonic and fetal beta-globin gene
repression by the orphan nuclear receptors, TR2 and TR4.” EMBO J. 2007, 26:2295-306.
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