|Reactivity||Human, Hamster, Pig, Rat|
|Calculated MW||36 KDa|
|Other Names||Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1|
|Target/Specificity||Synaptic immunoprecipitate (crude) from human brain.|
|Format||Protein G purified culture supernatant.|
|Antibody Specificity||The antibody is specific for the ~ 36 kDa syntaxin protein in Westernblots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalinfixed, vibratome sections. Does not work on paraffin sections.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Syntaxin 1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
(2007) Dual modes of Munc18-
1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
2007 Nov 7;27(45):12147-55
(2010) Deficits in syntaxin 1
phosphorylation in schizophrenia prefrontal cortex.
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in
cerebellum and visual cortex.
609, 9-20 (1993).
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