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Syntaxin 1A Antibody

Mouse monoclonal antibody

  • WB - Syntaxin 1A  Antibody AN1196
    Western blot of rat cortex lysate showing specific immunolabelingof the ~ 36k syntaxin 1A protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16623
Reactivity Human, Hamster, Pig, Rat
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names SP8
Calculated MW 36 KDa
Additional Information
Gene ID 6804
Gene Name STX1A
Other Names Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1
Target/Specificity Synaptic immunoprecipitate (crude) from human brain.
Dilution WB~~ 1:1000
Format Protein G purified culture supernatant.
Antibody Specificity The antibody is specific for the ~ 36 kDa syntaxin protein in Westernblots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalinfixed, vibratome sections. Does not work on paraffin sections.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSyntaxin 1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).


Khvotchev M
Dulubova I
Sun J
Dai H
Rizo J
Südhof TC
(2007) Dual modes of Munc18-
1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
2007 Nov 7;27(45):12147-55
Castillo MA
Ghose S
Tamminga CA
Ulery-Reynolds PG
(2010) Deficits in syntaxin 1
phosphorylation in schizophrenia prefrontal cortex.
Biol Psychiatry.
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in
cerebellum and visual cortex.
Brain Research
609, 9-20 (1993).

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$ 365.00
Cat# AN1196
Availability: 7-10 days
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