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Syntaxin 1A Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q16623 |
| Reactivity | Human, Hamster, Pig, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 |
| Clone Names | SP8 |
| Calculated MW | 36 KDa |
| Gene ID | 6804 |
|---|---|
| Gene Name | STX1A |
| Other Names | Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1 |
| Target/Specificity | Synaptic immunoprecipitate (crude) from human brain. |
| Dilution | WB~~ 1:1000 |
| Format | Protein G purified culture supernatant. |
| Antibody Specificity | The antibody is specific for the ~ 36 kDa syntaxin protein in Westernblots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalinfixed, vibratome sections. Does not work on paraffin sections. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Syntaxin 1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
References
Khvotchev M
,
Dulubova I
,
Sun J
,
Dai H
,
Rizo J
,
Südhof TC
(2007) Dual modes of Munc18-
1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
J
Neurosci.
2007 Nov 7;27(45):12147-55
Castillo MA
,
Ghose S
,
Tamminga CA
,
Ulery-Reynolds PG
(2010) Deficits in syntaxin 1
phosphorylation in schizophrenia prefrontal cortex.
Biol Psychiatry.
67(3):208-16
Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in
cerebellum and visual cortex.
Brain Research
609, 9-20 (1993).
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