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Phospho-Ser394 HDAC2 Antibody

Affinity purified rabbit polyclonal antibody

  • WB - Phospho-Ser394 HDAC2 Antibody AN1247
    Western blot of mouse heart lysate showing specific immunolabeling of the ~55k HDAC2 protein phosphorylated at Ser394 (control). Phosphospecificity is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that the lysate was incubated in λ-Ptase (800 units/1mg protein for 30 min). The immunolabeling is completely eliminated by treatment with λ-Ptase.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92769
Reactivity Mouse
Predicted Bovine, Chicken, Human, Pig, Monkey, Rat
Host Rabbit
Clonality polyclonal
Calculated MW 55364 Da
Additional Information
Gene ID 3066
Gene Name HDAC2
Other Names Histone deacetylase 2, HD2, HDAC2
Target/Specificity Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser394 of human HDAC2.
Dilution WB~~ 1:1000
Format Prepared from rabbit serum by affinity purification via sequential chromatography on dephosphopeptide and phosphopeptide affinity columns.
Antibody Specificity Specific for the ~55k HDAC2 protein phosphorylated at Ser394 inWestern blots. Immunolabeling is completely blocked by λ-Phosphatase treatment (30 minutes,800units/1mg protein).
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-Ser394 HDAC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
ShippingBlue Ice
Research Areas
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Histone Deacetylase 2 (HDAC2) is part of a family of histone deacetylases that are responsible for deacetylation of lysine residues in the histone core. HDAC2 is classified as a class I histone deacetylase and is ubiquitously expressed throughout the body (Kee et al, 2008). It has been shown that HDAC2 plays an important role in cardiac hypertrophy (Eom et al, 2011). Phosphorylation of ser394 is responsible for the hypertrophy-associated activation of HDAC2, whereas intrinsic basal activity is maintained by phosphorylation of ser422 and ser424 (EOM et al, 2011).


Kee HJ, Eom GH, Joung H, Shin S, Kim JR Cho YK, Choe N, Sim BW, Jo D, Jeong MH, Kim KK, Seo JS,
Kook H (2008) Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac
hypertrophy. Cir Res 2008 Nov 21;103(11):1259-69.
Eom GH, Cho YK, Ko JH, Shin S, Choe N, Kim Y, Joung H, Kim HS, Nam KI, Kee HJ, Kook H (2011)
Casein Kinase-2α1 Induces Hypertrophic Respose by Phosphorylation of Histone Deacetylase 2
S394 and its activation in the Heart Clinical Perspective. Circulation May16, 2011;123:2392-2403.

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$ 365.00
Cat# AN1247
Availability: 7-10 days
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