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Anti-Collagen 1, alpha 1 propeptide Antibody
Our Anti-Collagen 1, alpha 1 propeptide primary antibody from PhosphoSolutions is rabbit polyclonal.
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P02452 |
| Reactivity | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 138911 Da |
| Gene ID | 1277 |
|---|---|
| Other Names | Alpha 1 type I collagen antibody, Alpha 2 type I collagen antibody, alpha 2 type I procollagen antibody, alpha 2(I) procollagen antibody, alpha 2(I)-collagen antibody, Alpha-1 type I collagen antibody, alpha1(I) procollagen antibody, CO1A1_HUMAN antibody, COL1A1 antibody, COL1A2 antibody, collagen alpha 1 chain type I antibody, Collagen alpha-1(I) chain antibody, collagen alpha-1(I) chain preproprotein antibody, Collagen I alpha 1 polypeptide antibody, Collagen I alpha 2 polypeptide antibody, collagen of skin tendon and bone, alpha-1 chain antibody, collagen of skin tendon and bone alpha-2 chain antibody, Collagen type I alpha 1 antibody, Collagen type I alpha 2 antibody, EDSC antibody, OI1 antibody, OI2 antibody, OI3 antibody, OI4 antibody, pro-alpha-1 collagen type 1 antibody, type I proalpha 1 antibody, type I procollagen alpha 1 chain antibody, Type I procollagen antibody |
| Target/Specificity | Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005) |
| Format | Antigen Affinity Purified |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Collagen 1, alpha 1 propeptide Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)
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