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Anti-Myelin Basic Protein (MBP) Antibody
Our Anti-Myelin Basic Protein (MBP) primary antibody from PhosphoSolutions is chicken polyclonal. It
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P02688 |
| Reactivity | Bovine, Chicken |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Calculated MW | 21502 Da |
| Gene ID | 24547 |
|---|---|
| Other Names | GDB antibody, Golli MBP antibody, Golli MBP myelin basic protein antibody, Hemopoietic MBP antibody, HMBPR antibody, HUGO antibody, MBP antibody, MBP_CAVPO antibody, MBP_HUMAN antibody, MGC99675 antibody, MLD antibody, Myelin A1 protein antibody, Myelin A1 Protein basic antibody, Myelin basic protein antibody, Myelin Deficient antibody, Myelin membrane encephalitogenic protein antibody, OTTHUMP00000163776 antibodym, OTTHUMP00000174387 antibody, OTTHUMP00000174388 antibody, SHI antibody, Shiverer antibody, SP antibody |
| Target/Specificity | Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago (Eylar et al., 1971). The protein is made by oligodendrocytes in the central nervous system, so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells (Marty et al., 2002). In the central nervous system there are there different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5, and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typically show two bands on Western blots, one at about 22 kDa and another at about 18 kDa. |
| Format | Total IgY fraction |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Myelin Basic Protein (MBP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago (Eylar et al., 1971). The protein is made by oligodendrocytes in the central nervous system, so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells (Marty et al., 2002). In the central nervous system there are there different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5, and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typically show two bands on Western blots, one at about 22 kDa and another at about 18 kDa.
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