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Anti-Synaptobrevin (VAMP) Antibody
Our Anti-Synaptobrevin (VAMP) primary antibody from PhosphoSolutions is mouse monoclonal. It detects
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Application 
| WB |
|---|---|
| Primary Accession | P23763 |
| Reactivity | Bovine, Chicken, Drosophila, C.Elegans, EBV, Neisseria Gonorrhoeae, Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone Names | SP10 |
| Calculated MW | 12902 Da |
| Gene ID | 6843 |
|---|---|
| Other Names | SYB antibody, SYB1 antibody, Synaptobrevin 1 antibody, VAMP antibody, VAMP1 antibody, Vesicle associated membrane protein 1 antibody |
| Target/Specificity | Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000). |
| Format | IgM Purified culture supernatant |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Synaptobrevin (VAMP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000).
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