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CHIT1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13231 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1D9G2; 1D9G4; 2B4G3 |
| Isotype | IgG1 |
| Calculated MW | 51681 Da |
| Description | CHIT1:chitinase 1 (chitotriosidase). Chitotriosidase is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. |
| Immunogen | Purified recombinant fragment of CHIT1 (aa22-137) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 1118 |
|---|---|
| Other Names | Chitotriosidase-1, 3.2.1.14, Chitinase-1, CHIT1 |
| Dilution | WB~~1/500 - 1/2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CHIT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHIT1 |
|---|---|
| Function | Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. |
| Cellular Location | Secreted. Lysosome. Note=A small proportion is lysosomal |
| Tissue Location | Detected in spleen. Secreted by cultured macrophages. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Sarcoidosis Vasc Diffuse Lung Dis. 2007 Mar;24(1):59-64. 2. Clin Biochem. 2007 Mar;40(5-6):365-9.
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