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eNOS Antibody
Purified Mouse Monoclonal Antibody
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Application 
| IHC, E |
|---|---|
| Primary Accession | P29474 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6H2 |
| Isotype | IgG1 |
| Calculated MW | 133kDa |
| Description | Endothelial nitric-oxide synthase (eNOS), also known as NOS3, it is an important enzyme in the cardiovascular system. It is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. |
| Immunogen | Purified recombinant fragment of human eNOS expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 4846 |
|---|---|
| Other Names | Nitric oxide synthase, endothelial, 1.14.13.39, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII, NOS3 |
| Dilution | IHC~~1/200 - 1/1000 E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | eNOS Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOS3 (HGNC:7876) |
|---|---|
| Function | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
| Cellular Location | Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity |
| Tissue Location | Platelets, placenta, liver and kidney. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Nature. 1999 Jun 10;399(6736):601-5. 2. Oncol Rep. 2004 Nov;12(5):1007-11. 3. Breast Cancer Res Treat. 2008 May;109(1):181-2.
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$ 325.00
Cat# AO1327a
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