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> home > Products > Primary Antibodies > Antibody Collections > Immune system process > CD38 Antibody
CD38 Antibody
Purified Mouse Monoclonal Antibody
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Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P28907 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6E12D |
| Isotype | IgG1 |
| Calculated MW | 34kDa |
| Description | CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance. |
| Immunogen | Purified recombinant fragment of human CD38 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 952 |
|---|---|
| Other Names | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 3.2.2.6, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2.4.99.20, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38, CD38 |
| Dilution | WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 IF~~1:200~1000. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD38 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD38 |
|---|---|
| Function | Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:8253715, PubMed:7961800). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:8253715, PubMed:7961800). |
| Cellular Location | Cell surface. Membrane; Single-pass type II membrane protein |
| Tissue Location | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1. Trends Biochem Sci. 1992 Dec;17(12):495. 2. J Cell Biol. 1999 Sep 6;146(5):1161-72. 3. Exp Hematol. 2002 Jun;30(6):582-9. 4. Mol Immunol. 2006 Mar;43(7):1029-39.
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$ 325.00
Cat# AO1338a
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