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PLA2G12A Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9BZM1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7C7C9 |
| Isotype | IgG1 |
| Calculated MW | 21kDa |
| Description | Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s |
| Immunogen | Purified recombinant fragment of human PLA2G12A (AA: 21-189) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
| Gene ID | 81579 |
|---|---|
| Other Names | Group XIIA secretory phospholipase A2, GXII sPLA2, sPLA2-XII, 3.1.1.4, Phosphatidylcholine 2-acylhydrolase 12A, PLA2G12A, PLA2G12 |
| Dilution | WB~~1/500 - 1/2000 FC~~1/200 - 1/400 E~~1/10000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLA2G12A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLA2G12A |
|---|---|
| Synonyms | PLA2G12 |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine. |
| Cellular Location | Secreted. Cytoplasm |
| Tissue Location | Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. ; ;
References
1. J Biol Chem. 2003 Mar 21;278(12):10657-67. 2. Biochemistry. 2003 Oct 7;42(39):11494-503.
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