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IRAK3 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, E |
|---|---|
| Primary Accession | Q9Y616 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5C3D6 |
| Isotype | IgG1 |
| Calculated MW | 67.8kDa |
| Description | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. |
| Immunogen | Purified recombinant fragment of human IRAK3 (AA: 454-596) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 11213 |
|---|---|
| Other Names | Interleukin-1 receptor-associated kinase 3, IRAK-3, 2.7.11.1, IL-1 receptor-associated kinase M, IRAK-M, IRAK3 {ECO:0000312|EMBL:AAH57800.1} |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 IF~~1/100-1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IRAK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IRAK3 {ECO:0000312|EMBL:AAH57800.1} |
|---|---|
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). |
| Cellular Location | Cytoplasm. Nucleus. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000250|UniProtKB:Q8K4B2} |
| Tissue Location | Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) (PubMed:29686383). Expressed predominantly in peripheral blood lymphocytes (PubMed:10383454) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2012;7(1):e30414.2.Am J Respir Cell Mol Biol. 2011 Oct;45(4):740-5.
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$ 385.00
Cat# AO2048a
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