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CALB2 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P22676 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 5E9B6 |
| Isotype | IgG1 |
| Calculated MW | 31.5kDa |
| Description | This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. |
| Immunogen | Purified recombinant fragment of human CALB2(AA: 1-271) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 794 |
|---|---|
| Other Names | Calretinin, CR, 29 kDa calbindin, CALB2, CAB29 |
| Dilution | WB~~1/500 - 1/2000 E~~1/10000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CALB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALB2 (HGNC:1435) |
|---|---|
| Synonyms | CAB29 |
| Function | Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways (PubMed:2001709). Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory (By similarity). During embryonic development, it facilitates neuronal differentiation and maturation (By similarity). |
| Cellular Location | Synapse {ECO:0000250|UniProtKB:Q08331}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q08331}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell {ECO:0000250|UniProtKB:Q08331} |
| Tissue Location | Brain. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Int J Cancer. 2013 Nov;133(9):2077-88.2.BMC Cancer. 2010 May 28;10:242.
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$ 385.00
Cat# AO2056a
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