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FOXM1 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q08050 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6F11A8 |
| Isotype | IgG1 |
| Calculated MW | 84.3kDa |
| Description | The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | Purified recombinant fragment of human FOXM1 (AA: 649-748) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 2305 |
|---|---|
| Other Names | Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, HFH-11, HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells, FOXM1, FKHL16, HFH11, MPP2, WIN |
| Dilution | E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOXM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOXM1 |
|---|---|
| Synonyms | FKHL16, HFH11, MPP2, WIN |
| Function | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors Not expressed in resting cells. Isoform 2 is highly expressed in testis |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Cancer Gene Ther. 2014 Mar;21(3):133-8.2.Mol Cancer. 2013 Dec 10;12:159.
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$ 385.00
Cat# AO2180a
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