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> home > Products > Primary Antibodies > Antibody Collections > Anti-Wnt-Pathway (plus Lgr5) Antibodies > Mouse Monoclonal Antibody to CDH11
Mouse Monoclonal Antibody to CDH11
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, FC, ICC, E |
|---|---|
| Primary Accession | P55287 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2C12A6 |
| Isotype | Mouse IgG1 |
| Calculated MW | 88kDa |
| Description | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. ; |
| Immunogen | Purified recombinant fragment of human CDH11 (AA: 468-617) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 ICC: 1/200 - 1/1000 FCM: 1/200 - 1/400 |
| Gene ID | 1009 |
|---|---|
| Other Names | OB; CAD11; CDHOB; OSF-4 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to CDH11 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDH11 |
|---|---|
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level) (PubMed:33811546) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Arthritis Rheumatol. 2014 Apr;66(4):1010-21. ; 2.Mol Cancer Res. 2012 Mar;10(3):293-304. ;
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$ 385.00
Cat# AO2334a
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