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Mouse Monoclonal Antibody to MOB1A
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9H8S9 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3E7B2 |
| Isotype | Mouse IgG1 |
| Calculated MW | 25kDa |
| Description | The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene.; |
| Immunogen | Purified recombinant fragment of human MOB1A (AA:1-216) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 FCM: 1/200 - 1/400 |
| Gene ID | 55233 |
|---|---|
| Other Names | MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to MOB1A is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MOB1A |
|---|---|
| Synonyms | C2orf6, MOB4B, MOBK1B, MOBKL1B |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. |
| Tissue Location | Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Biochem Genet. 2015 Oct;53(9-10):268-79. ; 2.Int J Oncol. 2007 Aug;31(2):333-8.;
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$ 385.00
Cat# AO2342a
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