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> home > Products > Primary Antibodies > Antibody Collections > Immunity > Mouse Monoclonal Antibody to C3C
Mouse Monoclonal Antibody to C3C
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P01024 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8B5H2 |
| Isotype | Mouse IgG1 |
| Calculated MW | 187.1kDa |
| Description | Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.; |
| Immunogen | Purified recombinant fragment of human C3C (AA: 1521-1649) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 |
| Gene ID | 718 |
|---|---|
| Other Names | ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p |
| Dilution | WB~~1:1000 IHC~~1:100~500 E~~N/A |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to C3C is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C3 {ECO:0000303|PubMed:2579379, ECO:0000312|HGNC:HGNC:1318} |
|---|---|
| Function | Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. |
| Cellular Location | Secreted. [C3a anaphylatoxin]: Secreted |
| Tissue Location | Plasma.. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Blood. 2015 Apr 9;125(15):2359-69. ; 2.Mediators Inflamm. 2013;2013:716902.;
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$ 385.00
Cat# AO2388a
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