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> home > Products > Primary Antibodies > Antibody Collections > Immunity > Mouse Monoclonal Antibody to C1QA
Mouse Monoclonal Antibody to C1QA
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, E |
|---|---|
| Primary Accession | P02745 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8B5B1 |
| Isotype | Mouse IgG2a |
| Calculated MW | 26kDa |
| Description | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.; |
| Immunogen | Purified recombinant fragment of human C1QA (AA: 23-167) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 IHC: 1/200 - 1/1000 FCM: 1/200 - 1/400 |
| Gene ID | 712 |
|---|---|
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to C1QA is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C1QA |
|---|---|
| Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
| Cellular Location | Secreted. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Immunology. 2012 May;136(1):78-85. ; 2.Br J Cancer. 2010 Apr 13;102(8):1294-9.;
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$ 385.00
Cat# AO2437a
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