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CIRBP
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | Q14011 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6E12D5 |
| Isotype | Mouse IgG1 |
| Calculated MW | 18.6kDa |
| Immunogen | Purified recombinant fragment of human CIRBP (AA: 1-90) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 1153 |
|---|---|
| Other Names | CIRP |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 IHC~~1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CIRBP is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CIRBP |
|---|---|
| Synonyms | A18HNRNP, CIRP |
| Function | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'- UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. |
| Cellular Location | Nucleus, nucleoplasm. Cytoplasm Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). |
| Tissue Location | Ubiquitous. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2015 Sep 11;10(9):e0137721.2.Med Sci Monit. 2015 May 2;21:1256-60.
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$ 385.00
Cat# AO2552a
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