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P2RY8
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | Q86VZ1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1G5A11 |
| Isotype | Mouse IgG2a |
| Calculated MW | 40.6kDa |
| Immunogen | Purified recombinant fragment of human P2RY8 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 286530 |
|---|---|
| Other Names | P2Y8 |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 ICC~~ 1/100 - 1/500 IHC~~ 1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2RY8 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RY8 {ECO:0000303|PubMed:30842656, ECO:0000312|HGNC:HGNC:15524} |
|---|---|
| Function | G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain (PubMed:11004484, PubMed:15466006). Expressed in B cells and follicular helper T cells in germinal centers (at protein level) (PubMed:30842656). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Exp Med. 2015 Dec 14;212(13):2213-22. 2.Blood. 2010 Jul 1;115(26):5393-7.
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$ 385.00
Cat# AO2636a
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