AEBP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q8IUX7 |
Other Accession | NP_001120.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 130929 Da |
Antigen Region | 334-364 aa |
Gene ID | 165 |
---|---|
Other Names | Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein, AEBP1, ACLP |
Target/Specificity | This AEBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-364 amino acids from the Central region of human AEBP1. |
Dilution | WB~~1:8000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | AEBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AEBP1 |
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Synonyms | ACLP |
Function | [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. |
Cellular Location | [Isoform 1]: Secreted {ECO:0000250|UniProtKB:Q640N1} |
Tissue Location | Expressed in osteoblast and visceral fat. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells.
References
Majdalawieh, A., et al. Nucl Recept Signal 8, E004 (2010) :
Schissel, S.L., et al. Am. J. Pathol. 174(3):818-828(2009)
Zhang, L., et al. Mol. Med. 11 (1-12), 39-47 (2005) :
Layne, M.D., et al. Mol. Cell. Biol. 21(15):5256-5261(2001)
Muise, A.M., et al. Biochem. J. 343 PT 2, 341-345 (1999) :
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