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BCMO1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HAY6 |
| Other Accession | NP_059125.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62637 Da |
| Antigen Region | 263-292 aa |
| Gene ID | 53630 |
|---|---|
| Other Names | Beta, beta-carotene 15, 15'-monooxygenase, Beta-carotene dioxygenase 1, Beta-carotene oxygenase 1 {ECO:0000312|HGNC:HGNC:13815}, BCO1 (HGNC:13815) |
| Target/Specificity | This BCMO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human BCMO1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BCMO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCO1 (HGNC:13815) |
|---|---|
| Function | Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9I993} |
| Tissue Location | Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules.
References
Lietz, G., et al. Arch. Biochem. Biophys. 502(1):8-16(2010)
Kim, Y.S., et al. Biotechnol. Lett. 32(6):847-853(2010)
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Perry, J.R., et al. Diabetologia 52(10):2117-2121(2009)
Ferrucci, L., et al. Am. J. Hum. Genet. 84(2):123-133(2009)
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