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RTP4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q96DX8 |
| Other Accession | NP_071430.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27863 Da |
| Antigen Region | 186-215 aa |
| Gene ID | 64108 |
|---|---|
| Other Names | Receptor-transporting protein 4, 28 kDa interferon-responsive protein, RTP4, IFRG28 |
| Target/Specificity | This RTP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the C-terminal region of human RTP4. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RTP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTP4 |
|---|---|
| Synonyms | IFRG28, Z3CXXC4 |
| Function | Chaperone protein that facilitates the trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs) (PubMed:18836069). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (PubMed:33113352). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (By similarity). In addition, restores antiviral signaling by interacting with and sequestering influenza A virus protein NS1 (PubMed:39798334). |
| Cellular Location | Membrane; Single-pass type III membrane protein. Cytoplasm |
| Tissue Location | Expressed in circumvallate papillae and testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
RTP4 belongs to the TMEM7 family. The function of this protein remains unknown.
References
Behrens, M., et al. J. Biol. Chem. 281(29):20650-20659(2006)
Clark, A.J., et al. Trends Endocrinol. Metab. 16(10):451-457(2005)
Saito, H., et al. Cell 119(5):679-691(2004)
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