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CLEC10A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8IUN9 |
| Other Accession | NP_878910.1, NP_006335.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35446 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 10462 |
|---|---|
| Other Names | C-type lectin domain family 10 member A, C-type lectin superfamily member 14, Macrophage lectin 2, CD301, CLEC10A, CLECSF13, CLECSF14, HML |
| Target/Specificity | This CLEC10A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CLEC10A. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLEC10A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC10A |
|---|---|
| Synonyms | CLECSF13, CLECSF14, HML |
| Function | Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. |
| Cellular Location | Membrane; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLEC10A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Iijima, M., et al. Neurology 73(17):1348-1352(2009)
van Vliet, S.J., et al. PLoS Pathog. 5 (10), E1000625 (2009) :
Suzuki, N., et al. J. Immunol. 156(1):128-135(1996)
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