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DNAJB8 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NHS0 |
| Other Accession | NP_699161.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25686 Da |
| Antigen Region | 41-69 aa |
| Gene ID | 165721 |
|---|---|
| Other Names | DnaJ homolog subfamily B member 8, DNAJB8 |
| Target/Specificity | This DNAJB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human DNAJB8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DNAJB8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAJB8 |
|---|---|
| Function | Efficient suppressor of aggregation and toxicity of disease- associated polyglutamine proteins. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNAJB8 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM].
References
Hageman, J., et al. Mol. Cell 37(3):355-369(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ohtsuka, K., et al. Cell Stress Chaperones 5(2):98-112(2000)
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